Thyroid dysfunction in HIV infected patients with highly active antiretroviral therapy

Abstract

Thyroid dysfunction may be common in HIV infection and also in cases of highly active antiretroviral therapy. The study is cross-sectional analysis, which determined the relationship of thyroid dysfunction in HIV-infected patients with highly active antiretroviral therapy associated with the duration of therapy, CD4 count and viral load in the Comprehensive Care Clinic of Zacapa, Guatemala. With randomized probabilistic sampling of 218 patients stratifying them into subgroups in relation to the years of use of highly active antiretroviral therapy, TSH and free T4 were performed, associating it with time of antiretroviral therapy, viral load and CD4. The association between the duration of the use of Antiretroviral Therapy of Great Activity-TRARGA, and the prevalence of thyroid dysfunction (p <0.001) was determined.Prophylaxis administered to prevent opportunistic infections was associated with subclinical hypothyroidism (p = 0.004, RP = 3.81). Patients with subclinical hypothyroidism had a higher intensity of symptoms such as insomnia, dry skin, among others. It was verified that the presence of subclinical hypothyroidism is related to the time of antiretroviral use, and to the use of prophylaxis for opportunistic infections, which may be due to the immunological compromise that this type of patients presents, and may have effects on the system. endocrine, or an endocrine complication typical of therapy.